Drugs Home > Tolvaptan Dosage

With tolvaptan, your dosage is calculated based on how you respond to the drug, other medications you are taking, and various other considerations. This prescription medication comes as a tablet that is taken once a day. Do not drink grapefruit juice while using this medication, as it can increase the amount of tolvaptan in your blood.

An Introduction to Your Dosage of Tolvaptan

The dose of tolvaptan (Samsca®) your healthcare provider recommends will vary, depending on:
  • How you respond to the medication
  • Other medications you are taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Tolvaptan Dosing Guidelines

The initial recommended dose of tolvaptan for treating hyponatremia (low blood sodium levels) is 15 mg once a day. After at least 24 hours of treatment, your healthcare provider may increase your dose if your sodium blood levels have not sufficiently improved. The maximum recommended tolvaptan dose is 60 mg a day.
Raising blood sodium levels too quickly can cause a potentially serious problem known as osmotic demyelination syndrome. You will start tolvaptan in the hospital, where your blood sodium levels can be monitored closely. 

General Information on Taking Tolvaptan

Some considerations to keep in mind during treatment with tolvaptan include the following:
  • Tolvaptan comes in tablet form. It is usually taken by mouth once a day.
  • You can take tolvaptan with food or on an empty stomach.
  • You will need to start tolvaptan in the hospital so you can be closely monitored at the beginning of treatment.
  • Try to take this medication at the same time each day to keep an even level of the drug in your blood.
  • You should continue to drink fluids if you are thirsty during treatment with tolvaptan.
  • Do not drink grapefruit juice while taking this medicine. Grapefruit juice can increase the amount of tolvaptan in your blood.
  • For the medication to work properly, it must be taken as prescribed. Do not stop and restart this medicine on your own. If you stop taking it, you will need to restart it in the hospital.
  • If you are unsure about anything related to your dosage of tolvaptan, please talk with your healthcare provider, nurse, or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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