Tiludronate: What Should I Tell My Healthcare Provider?
You should talk with your healthcare provider prior to taking tiludronate if you:
- Have kidney disease, including kidney failure (renal failure)
- Have any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
How Does Tiludronate Work?
Tiludronate belongs to a group of medications known as bisphosphonates. The drug binds to certain cells in bones and slows the breakdown of bone. Normally, bone is continuously being broken down and rebuilt. Paget's disease of the bone is a condition involving rapid breakdown of bone combined with abnormal reformation of bone. The abnormally reformed bone is weaker than normal. Bisphosphonates, such as tiludronate, can help slow the breakdown of bone and can help the body build bone more normally.
One way to assess the severity of Paget's disease is by measuring the level of alkaline phosphate in the blood. In studies, tiludronate was shown to decrease alkaline phosphate levels, which indicates that it helps to improve Paget's disease.
Studies compared three months of tiludronate use with six months of Didronel®
) use, a similar medication used to treat Paget's disease. On average, tiludronate lowered alkaline phosphate levels significantly more than tiludronate, even though it is taken for half as long.