Drugs Home > Tacrolimus Side Effects

Headaches, diarrhea, and insomnia are some of the most commonly reported side effects with tacrolimus. In most cases, reactions such as these tend to be minor and easy to treat. However, contact your healthcare provider immediately if you develop potentially serious problems, such as chest pain, unusual bruising, or swollen glands in the neck, armpits, or groin.

An Introduction to Tacrolimus Side Effects

Just like any medicine, tacrolimus (Prograf®, Protopic®) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with tacrolimus. Your healthcare provider can discuss a more complete list with you.)

Serious Side Effects of Tacrolimus

Some tacrolimus side effects are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of infection, such as:
    • High fever
    • Aches and pains
    • Coughing
    • Chills
  • Sores or wounds that appear infected or do not heal
  • Swollen glands in the neck, armpits, or groin
  • Symptoms of a gastric perforation, such as severe stomach pain, nausea, vomiting, and fever/chills
  • Any skin changes, such as discoloration, sores, or lumps
  • Shortness of breath
  • Chest pain
  • Urinating less often than usual, or not at all
  • Signs of high blood sugar levels, such as:
    • Frequent urination
    • Increased thirst
    • Blurred vision
  • Vision changes
  • Confusion
  • Problems with speech or coordination
  • Tremors
  • Headaches
  • Numbness and tingling sensations of the skin
  • Signs of anemia, such as:
    • Fatigue
    • Dizziness
    • Pale skin
  • Swelling in the arms, legs, ankles, or feet
  • Increased blood pressure (hypertension)
  • An irregular heartbeat
  • Unusual bleeding or bruising
  • Seizures
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth or throat
    • Wheezing
    • Difficulty breathing or swallowing.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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