Drugs Home > Sirolimus Side Effects

Common side effects of sirolimus include increased triglycerides, high blood pressure, and swelling of the hands. Because there is no way to know if you will experience problems with a medication you have never tried, it's hard to know if reactions will occur in your particular case. If side effects do occur, or even if something "just doesn't seem right," tell your healthcare provider.

An Introduction to Sirolimus Side Effects

Just like any medicine, sirolimus (Rapamune®) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with sirolimus. Your healthcare provider can discuss a more complete list with you.)

Serious Side Effects

Some sirolimus side effects are potentially serious and should be reported immediately to your healthcare provider. These reactions include but are not limited to:
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing or difficulty breathing
    • Difficulty swallowing
  • Signs of infection, such as high fever, chills, aches and pains, or coughing
  • Sores or wounds that do not heal, drain fluid, or appear red or infected
  • Swollen glands in the neck, armpits, or groin
  • Any skin changes, such as discoloration, sores, or lumps
  • Swelling (edema) in your hands, feet, ankles, legs, or other areas of your body
  • Difficulty breathing or shortness of breath
  • Confusion, problems thinking or walking, or weakness on one side of your body
  • Red, itchy, scaly skin
  • A decrease in the amount of urine produced
  • Fatigue, pale skin, dizziness, or shortness of breath
  • Unusual bruising or bleeding
  • Increased blood pressure (hypertension).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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