Drugs Home > Drug Interactions With Sirolimus

P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a natural protein that helps remove substances, such as medications, out of the tissues, so they can be excreted through the urine or feces. Pgp helps remove sirolimus from the body. Medications known as Pgp inhibitors decrease the activity of Pgp.
When sirolimus is taken with a Pgp inhibitor, it may be removed from the body more slowly, potentially increasing sirolimus blood levels and the risk for side effects. Your healthcare provider may choose to monitor you more closely if you take these drugs together and lower your dose if needed.
It is recommended that people taking immunosuppressants such as sirolimus not use pimecrolimus because of the increased risk for infection, lymphoma (cancer of the lymph nodes), and skin cancer. Talk to your healthcare provider before taking these drugs together.
Taking sirolimus with sipuleucel-T may make sipuleucel-T less effective. Talk to your healthcare provider before taking these medicines together.
Combining sirolimus with tacrolimus may increase your risk for potentially serious side effects, including kidney problems, development of diabetes, and slow wound healing. You should talk to your healthcare provider before taking these medicines together.

Final Thoughts

It is possible that not all drug interactions with sirolimus were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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