Drugs Home > Ruxolitinib

If you have intermediate-risk or high-risk myelofibrosis, ruxolitinib may be used to help relieve symptoms and reduce the size of your spleen. This prescription medicine comes in tablet form and is typically taken twice a day. It works by preventing the formation of abnormal blood cells. Most people who take this drug will experience some type of side effect, such as headaches, bruising, or dizziness.

What Is Ruxolitinib?

Ruxolitinib (Jakafi™) is a prescription medication approved to treat a disorder of the bone marrow known as myelofibrosis. Myelofibrosis is characterized by scarring of the bone marrow. Ruxolitinib is used to treat people who are considered intermediate-risk or high-risk, based on their expected survival. It belongs to a class of medicines known as kinase inhibitors.
(Click What Is Ruxolitinib Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, ruxolitinib can cause side effects. Although not everyone who takes this medication will have problems, most people will experience some type of side effect with this drug. Your healthcare provider can help you manage some of the reactions you may experience.
Common side effects of ruxolitinib include but are not limited to:
  • Low blood cell counts
  • Bruising
  • Dizziness
  • Headaches.
(Click Ruxolitinib Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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