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More Information on Drug Interactions With PTU

The following sections explain in detail the potentially negative interactions that can occur when PTU is combined with any of the drugs listed above.
Beta Blockers
Beta blockers are often given to people with hyperthyroidism in order to control the heart rate and blood pressure. Because hyperthyroidism affects how the body handles beta blockers, your healthcare provider will probably need to lower the dosage of your beta blocker as your condition improves.
Hyperthyroidism also affects how the body handles digoxin, so your healthcare provider may need to lower your digoxin dosage as your condition improves.
Sodium Iodide I 131
PTU may interfere with the effectiveness of sodium iodide I 131 (a radioactive iodine medication). People are generally advised to stop taking PTU for three to four days before treatment with sodium iodide I 131.
Because hyperthyroidism affects how the body handles theophylline, your healthcare provider may need to lower your theophylline dosage as your condition improves.
PTU and warfarin may interact unpredictably, and changes in thyroid hormone levels may also affect how the body responds to warfarin. Therefore, your healthcare provider should monitor you closely, both while you are taking PTU and after you stop taking it, and make any necessary adjustments to your warfarin dosage.

Final Thoughts

It is possible that not all drug interactions with PTU were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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