Drugs Home > Propoxyphene Hydrochloride Dosage

Before prescribing a dosage of propoxyphene hydrochloride, your healthcare provider will consider how you respond to the drug and other medical conditions you have, among other things. This prescription medication comes in the form of a capsule and is typically taken every four hours as needed for pain. Do not take more than 6 capsules in a 24-hour period.

An Introduction to Your Propoxyphene Hydrochloride Dosage

In November 2010, the United States Food and Drug Administration (FDA) withdrew all medications that contain propoxyphene from the market. It has been determined that the risks of propoxyphene outweigh the possible benefits. In particular, the FDA was concerned about the drug's ability to cause serious changes in the heart rhythm, even at normal doses. Pharmacies will no longer sell this medication, and people who take it should stop and ask their healthcare provider for a more suitable pain medication.


The dose of propoxyphene hydrochloride (Darvon®) that your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to propoxyphene hydrochloride
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically instructs you to do so.

Propoxyphene Hydrochloride Dosing for Pain

The standard recommended dose of propoxyphene hydrochloride for treating pain is one capsule (65 mg) every four hours as needed. Do not take more than 6 capsules in 24 hours.
If you have been taking propoxyphene hydrochloride on a long-term basis, it is probably best to stop taking it gradually, under the supervision of a healthcare provider. Stopping it too quickly could lead to unpleasant (although rarely dangerous) withdrawal symptoms. Typically, decreasing the dosage by 25 to 50 percent each day works well.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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