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Prednisone Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when prednisone is combined with any of the drugs listed above.
Barbiturates may decrease the level of prednisone in your blood, perhaps making it less effective. If you are taking these drugs together, your healthcare provider may need to increase your prednisone dosage.
Certain Diuretics
Prednisone can decrease the level of potassium in your blood. Taking prednisone with certain diuretics can increase this risk. If you are taking these medicines together, your healthcare provider should monitor your potassium levels and may prescribe a potassium supplement if necessary.
Diabetes Medications
Prednisone can cause high blood sugar (hyperglycemia) in some people. Your healthcare provider may need to increase the doses of your diabetes medications while you are taking prednisone.
Estrogens may increase the effects (and the side effects) of prednisone by various mechanisms. Your healthcare provider may need to adjust your prednisone dose, especially when you are starting or stopping an estrogen medication.
Live Vaccinations
People with a weak immune system should generally not receive live vaccines. Since prednisone may weaken the immune system, during treatment with prednisone you should talk with your healthcare provider before receiving any vaccinations.
Mifepristone (Mifeprex)
Taking mifepristone with prednisone may decrease the effectiveness of prednisone or cause other problems. Talk with your healthcare provider before taking these medications together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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