Drugs Home > Phenergan Drug Interactions

If pramlintide, anticholinergic drugs, or monoamine oxidase inhibitors are taken together with Phenergan, drug interactions may occur. These interactions may lead to undesirable side effects (such as drowsiness or dizziness) or reduce the effectiveness of the medications. Many other medicines may also cause drug interactions with Phenergan, so make sure to tell your healthcare provider about all other medications you are taking before starting treatment.

An Overview of Phenergan Interactions

Phenergan® (promethazine hydrochloride) can potentially interact with several other medications. Some of the medicines that may lead to drug interactions with Phenergan include:
 
  • Alcohol
  • Acetylcholinesterase inhibitor medications, such as:
 
 
  • Anticholinergic drugs, such as:
 
 
  • CYP 2B6 inhibitor medications, such as:
 
 
  • CYP 2D6 inhibitor medications, such as:
 
 
  • Epinephrine
  • Monoamine oxidase inhibitors (MAOIs), such as:
 
 
  • Other medications that cause drowsiness, such as:
 
 
It should be noted that this article applies only to Phenergan products that contain only promethazine as the active ingredient. Some cough syrups (such as Phenergan with Codeine) contain other active ingredients as well.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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