Drugs Home > Pentazocine/Naloxone

Available in the form of a tablet, pentazocine/naloxone is prescribed for use in people who have moderate-to-severe pain. This medicine is a type of controlled substance, meaning it is highly regulated and has a potential for abuse. It is usually taken every three or four hours. Although most people tolerate this pain reliever well, side effects are possible and include headaches, sweating, and constipation.

What Is Pentazocine/Naloxone?

Pentazocine/naloxone (Talwin® Nx) is a prescription medication approved to treat moderate-to-severe pain. It contains a combination of two active ingredients: pentazocine (Talwin®), a potent pain reliever, and naloxone (Narcan®), which is added to help deter misuse of pentazocine/naloxone by injection.
Pentazocine/naloxone is considered a schedule IV controlled substance because it has the potential for abuse or addiction. As a controlled substance, the possession and use of the drug are highly regulated. Schedule IV substances are considered to have less abuse potential than schedule II drugs, such as morphine, or schedule III drugs, such as hydrocodone/APAP.  
(Click What Is Pentazocine/Naloxone Used For? for more information, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, pentazocine/naloxone can cause side effects. However, not everyone who takes the drug will experience problems. In fact, most people tolerate it quite well.
If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
Some of the possible side effects of pentazocine/naloxone include but are not limited to:
(Click Pentazocine/Naloxone Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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