It is not known exactly what to expect from a palonosetron overdose. In studies, doses up to six times the normal dose were used without causing any problems, other than the usual side effects. Extremely large doses (equivalent to 947 times the usual dose) are lethal to rats and mice, causing seizures, gasping, and death. There is no known antidote for an overdose, and the medication is unlikely to be removed from the body using dialysis.
If you happen to overdose on palonosetron, seek immediate medical attention.
How Should This Medication Be Stored?
Palonosetron injections should be stored at your healthcare provider's office. They should be stored at room temperature, away from light. Store the capsules at room temperature, away from moisture and heat. Be sure to keep them in an airtight container.
Keep this and all other medications out of the reach of children.
Aloxi Capsules [package insert]. Woodcliff Lake, NJ: Eisai, Inc.;2008 August.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: Approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed July 24, 2007.
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