Drugs Home > Palonosetron

Clinical Effects

In studies, injectable palonosetron was compared to ondansetron (Zofran®) and dolasetron (Anzemet®) for the prevention of nausea and vomiting. When used for chemotherapy that was fairly likely to cause vomiting, up to 81 percent of people taking palonosetron experienced no vomiting within the first 24 hours, compared to just 69 percent of those taking ondansetron. Palonosetron was not significantly better than dolasetron. It was also not significantly better than ondansetron when used for chemotherapy that was extremely likely to cause vomiting.
 
These studies also looked at delayed nausea and vomiting, which occurs after the first 24 hours after chemotherapy. Up to 74 percent of people taking palonosetron injections experienced no vomiting during the one to five days after chemotherapy, compared to just 55 percent of those taking ondansetron. Palonosetron was also more effective than dolasetron for preventing delayed vomiting.
 
Studies have shown that palonosetron injections are effective for preventing nausea and vomiting after surgery. In one study, 44 percent of people who were given the medication had no vomiting (and no need for other nausea or vomiting medications) in the first 24 hours after surgery, compared to just 19 percent of people who were not given palonosetron.
 
Lastly, studies have shown that the capsule form (which was developed after the injectable version) are at least as good as the injectable form for preventing nausea and vomiting in the first 24 hours after chemotherapy.
 

When and How to Take This Medicine

General considerations for when and how to take palonosetron include the following:
 
  • The medication comes in capsule or injection form. For chemotherapy, it is given 30 minutes (for the IV form) or one hour (for the capsule version) before chemotherapy. For surgery, it is given just before anesthesia is started.
 
  • Palonosetron should not be mixed with other medications in an IV.
     
  • For the medication to work properly, it must be taken as prescribed.
     
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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