Drugs Home > Precautions and Warnings With Omeprazole

When it comes to omeprazole, precautions and warnings to be aware of include things such as the potential risk of drug interactions and the safety of taking the drug while pregnant or breastfeeding. Prior to taking omeprazole, be sure to talk to your healthcare provider if you have liver disease or any allergies. Also, be sure to tell him or her about all of the medications you take, including prescription and non-prescription medications, vitamins, and herbal supplements.

Omeprazole: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking omeprazole (Prilosec®) if you have:
  • Liver disease, including liver failure or cirrhosis
  • Low blood magnesium (hypomagnesemia) 
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Omeprazole

Some of the warnings and precautions to be aware of prior to taking omeprazole include the following:
  • Studies indicate that people who take proton pump inhibitor medications (such as omeprazole) may be at an increased risk for broken bones. The risk appears to be highest for people who take such medications at high doses or for long periods (over a year). You and your healthcare provider should take this into account when deciding if the benefits of this medication outweigh the risks for your particular situation.


  • The use of proton pump inhibitors (including this medication) may increase the risk of a potentially serious condition known as Clostridium difficile-associated diarrhea (CDAD). If you develop diarrhea that does not seem to improve (especially if it is watery and accompanied by a fever and abdominal pain), seek immediate medical attention. 


  • Some of the symptoms of GERD, heartburn, and ulcers are similar to the symptoms of stomach cancer. Just because omeprazole helps your symptoms does not rule out the possibility of stomach cancer.
  • Tell your healthcare provider if you have liver disease, as omeprazole is generally not recommended for those with severe liver problems.


  • Proton pump inhibitors (PPIs), including omeprazole, may cause low blood magnesium levels (hypomagnesemia). Seek immediate medical attention if you develop any symptoms of hypomagnesemia, such as muscle spasms, an irregular heart rhythm (arrhythmia), or seizures. Your healthcare provider may want to check your magnesium levels periodically using a simple blood test. 


  • Omeprazole can interact with other medications (see Drug Interactions With Omeprazole).
  • Omeprazole is considered a pregnancy Category C medication. This means omeprazole may not be safe for use during pregnancy. Talk to your healthcare provider about the risks and benefits of using omeprazole during pregnancy (see Prilosec and Pregnancy).
  • Omeprazole passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Prilosec and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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