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When and How to Take Omeprazole

Some general considerations for when and how to take this drug include the following:
  • Omeprazole comes in capsule form or as packets used to make an oral suspension (liquid). It is taken by mouth once or twice a day. The nonprescription version is available in tablet and capsule form.


  • It is best taken on an empty stomach, half an hour before a meal.
  • Omeprazole capsules should not be chewed or crushed, as they contain tiny granules with a special coating that prevents stomach acid from destroying the medication. The nonprescription tablets should not be cut, crushed, or chewed.
  • For people who have difficulty swallowing capsules, omeprazole capsules (but not tablets) can be opened and the contents sprinkled onto a spoonful of applesauce. The applesauce should not be hot and should be swallowed (without chewing) immediately.


  • For the oral suspension, the contents of one packet are mixed with a certain amount of water (which varies, depending on the strength), left to sit for two or three minutes to thicken, and taken within 30 minutes. Rinse out the container with a small amount of water and drink the contents if any of the drug remains. 


  • Your dosage should be taken at the same time(s) each day to maintain an even level of the medication in your blood.
  • For the medication to work properly, it must be taken as prescribed. It will not work if you stop taking it.

Dosing Information for Omeprazole

The dose of omeprazole that your healthcare provider recommends will vary, depending on a number of factors, including:
  • Your age
  • The medical condition being treated
  • Other medical conditions you may have
  • Other medications you may currently be taking.
As is always the case, do not adjust your omeprazole dose unless your healthcare provider specifically instructs you to do so.
(Click Omeprazole Dosing for more information.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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