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Drug Interactions With Nitroglycerin Tablets Explained

The following sections explain in detail the potentially negative reactions that can occur when nitroglycerin tablets are combined with any of the drugs listed above.
 
Alcohol
Combining alcohol with nitroglycerin tablets may increase the risk for low blood pressure (hypotension). Check with your healthcare provider before drinking alcohol while using nitroglycerin tablets.
 
Alteplase
Based on reports of a drug interaction with intravenous (IV) nitroglycerin, it is possible that nitroglycerin tablets could decrease the level of alteplase in the bloodstream, perhaps making it less effective. In the event that you need alteplase (which is sometimes used for people who are having a heart attack, blood clots, or certain types of strokes), make sure your healthcare provider knows you have been using nitroglycerin tablets.
 
Anticholinergics
Anticholinergic drugs have a tendency to cause a dry mouth, making it difficult to dissolve nitroglycerin tablets in the mouth. Chewing gum or mouth products (such as Biotene®) specifically designed to treat a dry mouth may help with this problem.
 
Blood Pressure Medications
Combining nitroglycerin tablets with blood pressure medications may cause dangerously low blood pressure. Your blood pressure may need to be closely monitored if you take these medications together.
 
Ergot Medications
Ergot medications can make nitroglycerin tablets less effective at relieving chest pain (angina). Also, nitroglycerin tablets may increase the level of ergot medications in the blood, increasing the risk for ergot side effects. In general, this combination of medications should be avoided if possible.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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