Drugs Home > Niacin Extended-Release/Simvastatin

Niacin extended-release/simvastatin is a medication often prescribed to treat high cholesterol and triglycerides. It contains two different active components, one of which works by blocking a particular enzyme that controls the rate of cholesterol production in the body. The medicine comes in tablet form and is generally taken once a day at bedtime. Potential side effects include nausea, flushing, and back pain.

What Is Niacin Extended-Release/Simvastatin?

Niacin extended-release/simvastatin (Simcor®) is a prescription medication used for treating unhealthy triglyceride or cholesterol levels. It contains two different cholesterol medications -- simvastatin (Zocor®) and extended-release niacin (Niaspan®).
(Click What Is Niacin Extended-Release/Simvastatin Used For? for more information, including possible off-label uses.)

Possible Side Effects

As with any medicine, there are possible side effects with niacin extended-release/simvastatin, but not everyone who takes it will have problems. In fact, most people tolerate the drug quite well. When people do develop side effects, in most cases, they are minor, meaning they require no treatment or are easily treated by you or a healthcare professional. If side effects do occur, most people do not need to stop their medicine.
Some of the most common side effects thought to be related to niacin extended-release/simvastatin include:
  • Flushing (sudden reddening and warmth of the face, neck, and/or upper chest)
  • Headache
  • Itching
  • Nausea
  • Back pain
  • Diarrhea.
Keep in mind that if you experience unexplained muscle pain, tenderness, or weakness, (especially if these symptoms are accompanied by a fever or a feeling of illness), it is important to contact your healthcare provider immediately. This could be a sign of a serious, life-threatening muscle problem (see Simcor and Muscle Pain for more information).
(Click Side Effects of Niacin Extended-Release/Simvastatin to learn more.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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