Drugs Home > Naltrexone Side Effects

Let your healthcare provider know right away if you are taking naltrexone and experience side effects like hallucinations, fainting, or thoughts of harming yourself. These and other serious problems can occur with this medication and require urgent medical treatment. In most cases, however, adverse reactions tend to be minor and can include things like nausea, headaches, and nervousness.

An Introduction to Side Effects With Naltrexone

Just like any medicine, naltrexone (Revia®) can cause side effects. However, not everyone who takes the medication will experience problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with naltrexone. Your healthcare provider can discuss a more complete list with you.)

Serious Naltrexone Side Effects

Some side effects of naltrexone are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Depression or low mood
  • Thoughts of suicide, harming yourself, or ending your life
  • Unusual behavior or mood, including irritability, agitation, or anxiety
  • Seeing or hearing things that are not real (hallucinations)
  • Feeling disoriented, confused, or paranoid
  • Swelling, pain, warmth, or redness in an arm or leg
  • A fast, forceful, or irregularly beating heart
  • Dizziness or fainting
  • Signs of liver problems, such as:
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Abdominal (stomach) pain
    • Loss of appetite
    • Dark urine
    • Pale or clay-colored stool
  • Signs of opioid withdrawal, such as:
    • Tearfulness
    • Nausea and vomiting
    • Abdominal (stomach) cramps
    • Restlessness
    • Bone, joint, or muscle pain
    • Runny or stuffy nose
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.  
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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