Drugs Home > Naltrexone Dosage

The recommended dose of naltrexone will be different for each person, depending on the reason they are taking this drug, how well it is tolerated, and other factors. If you develop side effects, your healthcare provider may lower your amount. Naltrexone comes as a tablet that is taken once daily. You should not take this medicine if you have taken an opioid in the last 7 to 10 days.

An Introduction to Your Dosage of Naltrexone

The dose of naltrexone (Revia®) your healthcare provider recommends will vary, depending on a few factors, including:
  • Why you are taking naltrexone
  • How you respond to it
  • Whether you will be taking the medication on your own or if someone else will be giving it to you.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Dosing for Alcohol Dependence

The recommended dosage for treating alcohol dependence is usually 50 mg once a day. If you experience side effects, such as significant nausea, your healthcare provider may recommend you take naltrexone 25 mg a day until your symptoms subside and then increase this amount to 50 mg a day. Alternatively, some healthcare providers may recommend 25 mg twice a day to help limit side effects.

What Is the Recommended Naltrexone Dosage for Opioid Dependence?

The recommended initial naltrexone dosage for the treatment of opioid dependence is usually 25 mg once a day. Unless symptoms of opioid withdrawal occur, this amount is usually increased to 50 mg a day.
You should not take naltrexone if you have taken an opioid in the past 7 to 10 days (for most opioids) or in the past two weeks for medications containing buprenorphine or methadone, since those opioids are long acting. Your healthcare provider may check for the presence of opioids in your system by testing your urine or by giving you a medication called naloxone (Narcan®). People who have recently taken opioids will develop opioid withdrawal symptoms when given naloxone.
A healthcare provider may sometimes recommend supervised administration of naltrexone, which means someone will give you the medication to ensure you are taking it. In such cases, alternative dosing strategies may be needed, such as taking 100 mg every other day or 150 mg every three days. Your healthcare provider will recommend the best naltrexone dose for your particular situation.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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