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Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to using mitomycin if you have:
 
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Low platelet counts
  • A bleeding disorder
  • Lung disease
  • Any allergies, including to medications, foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
   
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
(Click Precautions and Warnings With Mitomycin to learn more, including information on who should not use the drug.)
 

How Does It Work?

Mitomycin works by preventing DNA from replicating. It does this by causing strands of DNA to bind to each other and become linked (known as "cross-linking"). The linked strands are unable to uncoil and separate, which is necessary for the DNA to make copies of itself. If the DNA cannot make copies of itself, cells cannot divide and multiply, which slows down or stops the growth and spread of cancer cells.
 

When and How to Use This Medicine

Some general considerations to keep in mind during treatment with mitomycin include the following:
 
  • Mitomycin comes in the form of a powder, which is dissolved in sterile water to form a liquid. It is usually given through a needle inserted into a vein (an intravenous, or IV, injection).
 
  • Doses are usually given once every six to eight weeks.
 
  • You will normally receive your injection by a healthcare provider in a healthcare setting, such as a hospital or clinic.
 
  • For mitomycin to work properly, it must be used as prescribed.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
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