Drugs Home > Mitomycin Dosage
People who receive mitomycin usually receive a dosage based on their height and weight. Other factors that may affect the amount include how well the medicine is tolerated and other existing medical conditions. Mitomycin comes as a powder that is dissolved in sterile water and then injected intravenously once every six to eight weeks. It is administered by a healthcare provider in a healthcare setting.
The dose of mitomycin (Mutamycin®) your healthcare provider recommends may vary, depending on several factors, such as:
- Your height and weight
- How you respond to and tolerate the medication
- Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
Like many chemotherapy drugs, mitomycin doses are based on body surface area, which is calculated using your height and weight. Doses based on body surface area are written as milligrams per meter squared (mg per m2).
The usual recommended dosage of mitomycin for the treatment of stomach or pancreatic cancer is 10 to 20 mg per m2. People with liver or kidney disease may be treated with lower amounts. Doses are usually given every six to eight weeks, depending on the number of white blood cells and platelets in your body.
Mitomycin causes myelosuppression (a decrease in the ability of the bone marrow to make blood cells). Your healthcare provider will monitor your blood cell counts after each dose and adjust your next dose based on how low your blood cell counts drop at their lowest level (called the nadir). You will not receive further doses until your platelets and white blood cell counts return to a normal level.
Your healthcare provider may stop treatment with mitomycin if your cancer continues to progress after two dosages. People who do not adequately respond to two doses of mitomycin are unlikely to gain additional benefit.