Drugs Home > Drug Interactions With Minoxidil

Combining certain medications with minoxidil may result in negative reactions. Even though minoxidil is applied topically to the scalp, sometimes enough of the medication can reach the bloodstream to interfere with other drugs. Interactions with minoxidil may occur with blood pressure medications, prostacyclin analogs, and certain topical products, to name a few.

An Overview of Minoxidil Interactions

Minoxidil (Rogaine®) is an over-the-counter (OTC) medication used to treat male and female pattern baldness. It may potentially interact with several other medications.
(This article applies only to minoxidil formulations that are applied on the scalp. An oral form of minoxidil is available by prescription and is used to treat severe hypertension. Oral minoxidil should not be used to treat hair loss, as it can cause serious side effects. Click Loniten for more information.)
Minoxidil is applied directly on the scalp. Although very little of the medication is expected to be absorbed into the bloodstream after normal use, in some cases (such as if the medication is applied to an inflamed or irritated scalp), enough of the medication may be absorbed to cause drug interactions. Additionally, minoxidil should not be used with other medications that are applied on the scalp.
Some of the drugs that may lead to minoxidil interactions include but are not limited to:


  • Prostacyclin analogs, such as:
    • Epoprostenol (Flolan®, Veletri®)
    • Iloprost (Ventavis®)
    • Treprostinil (Remodulin®, Tyvaso®)
  • Rituximab (Rituxan®)
  • Topical medications applied directly on the scalp, such as:
    • Corticosteroid creams and ointments, such as hydrocortisone (Cortaid®, Cortizone®, and several other products) or triamcinolone (Triderm® and several other products)
    • Petrolatum or petroleum jelly (Vaseline®)
    • Retinoid creams or gels, such as bexarotene (Targretin®) and tretinoin (Atralin™, Avita®, Renova®, Retin-A®, Tretin-X™).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation

Topics & Medications


Related Channels

eMedTV Links
Copyright © 2006-2020 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.