Drugs Home > Mevacor Drug Interactions

Fibrates
Combining a fibrate with Mevacor increases the risk of serious muscle problems. Combining Mevacor with gemfibrozil should be avoided. Combining Mevacor with other fibrates should be done cautiously with extra monitoring.
 
Danazol
Taking both danazol and Mevacor together may increase the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments. If you take danazol, the recommended starting Mevacor dosage is 10 mg daily, and the maximum recommended dosage is 20 mg daily.
 
Diltiazem
Taking both diltiazem and Mevacor together may increase the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis. Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments. If you take Mevacor, the recommended starting dosage is 10 mg daily, and the maximum recommended dosage is 20 mg daily.
  
Grapefruit
It is recommended that people on Mevacor not drink grapefruit juice, eat grapefruit, or use grapefruit supplements because it can increase the levels of Mevacor in the blood. This can increase the chances for developing a serious muscle problem (myopathy or rhabdomyolysis), which can cause the kidneys to stop working (see Mevacor and Muscle Pain).
 
If you are being treated with Mevacor and want to continue drinking grapefruit juice, talk to your doctor about other cholesterol medications that you can take.
 
Niacin
Both niacin and Mevacor alone can increase the chances for developing serious muscle problems. Therefore, it is thought that combining these medicines may cause an even greater risk. If you are taking both Mevacor and niacin, your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments. The dose of Mevacor should not exceed 20 mg per day.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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