Drugs Home > Drug Interactions With Megestrol ES

If you are about to start treatment with megestrol ES, it is important that your healthcare provider has a current list of any medications, vitamins, or supplements you are taking. Potentially dangerous interactions may occur if megestrol ES is combined with drugs like cyclosporine, aminoglutethimide, or indinavir. Some of these reactions may cause serious side effects or decrease the effectiveness of the medications.

An Overview of Megestrol ES Interactions

Megestrol ES (Megace® ES) may interact with a number of other products. Some of the drugs that can react with megestrol ES include but are not limited to:

More Information on Drug Interactions With Megestrol ES

The following sections explain in detail the potentially negative reactions that can occur when megestrol ES is combined with any of the drugs listed above.
Aminoglutethimide may decrease blood levels of megestrol ES, possibly making it less effective. Your healthcare provider may need to monitor you more closely if you take these medicines together to make sure megestrol ES is working for you.
Megestrol ES may increase the level of cyclosporine in your blood, potentially increasing your risk for cyclosporine side effects. Your healthcare provider may choose to monitor you more closely, and may give you a lower cyclosporine dose, if you take these medications together.
Megestrol ES can increase the level of dofetilide in your body, which could increase the chance of developing potentially serious dofetilide side effects. The manufacturer of dofetilide recommends these medicines not be used together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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