Drugs Home > Mefloquine

Drug Interactions

Mefloquine can potentially interact with several other medicines (see Drug Interactions With Mefloquine).

What If I Take an Overdose of Mefloquine?

As with any medication, it is possible to take too much mefloquine. If you happen to overdose on this drug, seek immediate medical attention.
(Click Lariam Overdose for more information.)

What Should I Do If I Miss a Dose?

If you forget to take a dose of mefloquine, take it as soon as you remember. If it is almost time for your next dose, simply skip the missed dose, and continue with your regular dosing schedule. Do not take two doses of mefloquine at the same time.

How Does This Medication Work?

Mefloquine belongs to the antimalarial class of drugs. Malaria is a blood infection caused by tiny parasites called Plasmodium. This medication treats malaria by killing the Plasmodium parasites; however, it is not known how mefloquine does this.

When and How to Take Mefloquine

Some general considerations include the following:
  • This medication comes in tablet form. It is usually taken as a one-time dose when used to treat malaria or once weekly when used to prevent malaria.
  • Mefloquine should be taken after a full meal to help prevent stomach upset, and with a full glass of water (at least eight ounces).
  • If you vomit after taking mefloquine, call your healthcare provider. He or she will tell you if you need to take another dose.
  • If you are using mefloquine to prevent malaria, make sure to take your mefloquine dose on the same day of the week to keep an even level of the medication in your bloodstream.
  • To prevent malaria, mefloquine is usually taken weekly starting between one and three weeks before travel to a malaria area, during travel, and for four weeks after returning.
  • If mefloquine tablets cannot be swallowed whole, they may be crushed and mixed with a small amount of water, milk, or other fluid. Because this medicine is very bitter, mixing the crushed tablet in chocolate syrup, jelly, or applesauce can make it taste better for young children.
  • If you are taking mefloquine to treat malaria, you should start to feel better within two days of beginning treatment. If you do not start to feel better, your healthcare provider may need to give you a different medication.
  • It is important to use protective clothing, bed nets, and insect repellents to protect you from being bitten by mosquitoes in a malaria area. Mefloquine alone may not prevent a malaria infection.
  • You will be given a medication wallet card with mefloquine. Make sure you carry it with you at all times while you are taking this medicine.
  • Make sure you continue to take this medication for the full treatment course, even if you start to feel better. Your infection may not be entirely gone, even though you feel better.
  • For the medication to work properly, it must be taken as prescribed.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation

Topics & Medications


Related Channels

eMedTV Links
Copyright © 2006-2021 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.