Drugs Home > Medroxyprogesterone Subcutaneous Injection

Medroxyprogesterone subcutaneous injection is a prescription drug licensed to prevent pregnancy and relieve pain caused by endometriosis. This medicine contains a synthetic version of the hormone progesterone and is injected just beneath the skin every 12 to 14 weeks. While most people tolerate the drug well, side effects are possible and may include weight gain, headaches, and an absence of menstruation.

What Is Medroxyprogesterone Subcutaneous Injection?

Medroxyprogesterone subcutaneous injection (depo-subQ Provera 104®) is an injectable prescription medication approved for the following uses:
  • Preventing pregnancy
  • Relieving pain from endometriosis, a condition in which the tissue that normally lines the uterus grows outside of the uterus.
Medroxyprogesterone subcutaneous injection contains medroxyprogesterone, a progestin hormone. It comes as a liquid that is injected into the tissue just below the skin. This is known as a subcutaneous (SC or subQ) injection.
Medroxyprogesterone subcutaneous injection is not the same medication as Depo-Provera® (medroxyprogesterone intramuscular injection). Both medicines are long-acting contraceptives (lasting up to three months with each shot) that contain the hormone medroxyprogesterone. However, Depo-Provera contains higher doses of medroxyprogesterone and is given as an intramuscular injection (into the muscle).
(Click What Is Medroxyprogesterone Subcutaneous Injection Used For? for more information on this topic, including possible off-label uses.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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