Drugs Home > Loteprednol

Drug Interactions

Loteprednol is probably unlikely to interact with other medicines (see Drug Interactions With Loteprednol).

Overdose Information

It is not clear what exactly to expect from an overdose with this medication. If you happen to overdose on this medication, seek immediate medical attention.
(Click Alrex Overdose or Lotemax Overdose for more information.)

What Should I Do If I Miss a Dose?

If you do not use your loteprednol as scheduled, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not use a double dose of this medicine.

How Does It Work?

Loteprednol belongs to a group of medications known as corticosteroids, or simply "steroids" for short. Steroids can have many different effects in the body, including anti-inflammatory and anti-allergy effects.
However, long-term use of steroids can cause bothersome and sometimes serious side effects, and this limits the usefulness of many steroids. Because loteprednol is an eye medication, its effects are generally limited to the eye. This helps prevent many of the long-term side effects of steroids.

When and How to Use This Medication

Some general considerations include the following:
  • This medication comes in the form of an eye drop, an eye gel, and an eye ointment. It is used in the affected eye(s) four times a day (or sometimes more often in certain situations, at least initially).


  • The eye drop form of this medication is a suspension, so you must shake it vigorously before each use. For the gel, turn the bottle upside down and shake once before each dose, to fill the tip.


  • For the ointment, apply a small amount (approximately a half-inch ribbon in the space between your lower lid and your eye. Pull your lower lid down a bit to create a small pocket.


  • For the drops, you must remove your contact lenses prior to use. In order to prevent the lens from absorbing the preservative in the medication, make sure to wait at least 10 minutes after using the drops before reinserting the lenses. Do not wear your contact lenses if your eye is still red.


  • For the ointment or gel, do not wear contact lenses at all during treatment.


  • To help prevent contamination of the medication, do not touch the tip of the dropper to any surface, including the surface of the eye.


  • For the medication to work properly, it must be used as directed.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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