Drugs Home > Lenalidomide Dosage

Before a healthcare provider prescribes a dosage of lenalidomide, he or she will take into consideration how well your kidneys work and the reason why you need to take this medication, among other factors. This drug comes as a capsule that is taken once daily with a large glass of water. Try to take your dose at the same time each day.

An Introduction to Dosing With Lenalidomide

The dosage of lenalidomide (Revlimid®) your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • The reason you are taking the medication
  • How you respond to the medication
  • How well your kidneys work.
 
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 

Lenalidomide Dosage for Multiple Myeloma

The usual recommended dose of lenalidomide for the treatment of multiple myeloma is 25 mg a day for 21 days, followed by 7 days of no medication. This 28-day cycle is then repeated. People with kidney disease will normally be started on a lower dosage.
 
Lenalidomide is given in combination with dexamethasone when used to treat multiple myeloma. The usual dose of dexamethasone is 40 mg daily on days 1 through 4, 9 through 12, and 17 through 20 of the first 4 cycles, followed by 40 mg daily given only on days 1 through 4 of each subsequent 28-day cycle.
 
People who experience potentially dangerous lenalidomide side effects, such as low blood cell counts, may need to temporarily stop taking this drug. The medication may be restarted, usually at a lower dose, when the side effects improve.
 

Lenalidomide Dosage for Myelodysplastic Syndrome

The usual recommended dosage for the treatment of myelodysplastic syndrome is 10 mg once a day. People with kidney disease are usually started on a lower amount.
 
People who experience potentially dangerous lenalidomide side effects, such as low blood cell counts, may need to temporarily stop treatment. The medicine may be restarted when the side effects improve, usually at a lower dose.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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