Drugs Home > Lansoprazole Precautions and Warnings

In case of the prescription drug lansoprazole, precautions and warnings include such things as being aware of potential interactions that may occur when the medication is taken with other medicines. Other precautions and warnings for lansoprazole users should be aware of concern nursing while taking the medication. People with liver disease or liver failure should make their doctor aware of their condition prior to starting lansoprazole.

Lansoprazole Precautions and Warnings: What to Do Before Starting the Medication

Prior to taking lansoprazole (sold under the brand name Prevacid®), let your healthcare provider know if you:
  • Have liver disease or liver failure
  • Have low blood magnesium (hypomagnesemia) 
  • Are pregnant or breastfeeding
  • Have any allergies.
It is also important to tell your healthcare provider about all of the medicines that you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Some Lansoprazole Precautions and Warnings

Some precautions and warnings to be aware of with lansoprazole include the following:
  • Studies indicate that people who take proton-pump inhibitor medications (such as lansoprazole) may be at an increased risk for broken bones. The risk appears to be highest for people who take such medications at high doses or for long periods of time (over a year). You and your healthcare provider should take this into account when deciding if the benefits of this medication outweigh the risks for your particular situation.


  • The use of proton pump inhibitors (including this medication) may increase the risk of a potentially serious condition known as Clostridium difficile-associated diarrhea (CDAD). If you develop diarrhea that does not seem to improve (especially if it is watery and accompanied by a fever and abdominal pain), seek immediate medical attention. 


  • Lansoprazole is considered a pregnancy Category B medication, which means that it has not been studied in pregnant women. However, when studied in animals, it showed no negative effects on unborn babies. If you are pregnant, discuss the safety of taking lansoprazole with your healthcare provider before starting the medication (see Is Prevacid Safe During Pregnancy? for more information).
  • If you have severe liver disease, your healthcare provider may use particular caution when treating you with lansoprazole.


  • Proton pump inhibitors (PPIs), including lansoprazole, may cause low blood magnesium levels (hypomagnesemia). Seek immediate medical attention if you develop any symptoms of hypomagnesemia, such as muscle spasms, an irregular heart rhythm (arrhythmia), or seizures. Your healthcare provider may want to check your magnesium levels periodically using a simple blood test. 
  • Lansoprazole passes through breast milk. Therefore, check with your healthcare provider before taking lansoprazole if you are breastfeeding (see Prevacid and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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