Drugs Home > Side Effects of Intravenous Acetaminophen

Common Side Effects

Intravenous acetaminophen has been studied extensively in clinical trials. In these studies, the reactions that occurred in a group of people who received intravenous acetaminophen were documented and then compared to the side effects that occurred in a similar group of people who were given a placebo (a medication that does not contain any active ingredients).
In these studies, the most common bothersome (but not usually dangerous) side effects of intravenous acetaminophen included:
  • Nausea -- in up to 34 percent of people 
  • Vomiting -- up to 15 percent
  • Headaches -- up to 10 percent
  • Insomnia -- up to 7 percent.

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while receiving intravenous acetaminophen or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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