Drugs Home > Precautions and Warnings With Intravenous Acetaminophen

Let your healthcare provider know if you have any medical issues, such as problems with your liver or kidneys, before receiving intravenous acetaminophen. Precautions and warnings with this drug also apply to people who have certain allergies and women who are pregnant or nursing. Also, some people should avoid this prescription medication, including those who have severe liver problems.

What Should I Tell My Healthcare Provider Before Receiving Intravenous Acetaminophen?

You should talk with your healthcare provider prior to receiving intravenous acetaminophen (Ofirmev™) if you have:
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Alcoholism
  • Kidney disease, such as kidney failure
  • Severe dehydration or excessive blood loss
  • Chronic malnutrition
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Intravenous Acetaminophen Precautions and Warnings

Some warnings and precautions to be aware of prior to receiving this medicine include the following:
  • Intravenous acetaminophen can damage the liver. Therefore, if you already have liver problems, you should talk to your healthcare provider before receiving this medication.
  • People with alcoholism, kidney problems, chronic malnutrition, severe dehydration, or excessive blood loss may have an increased risk for liver damage due to intravenous acetaminophen.
  • This drug contains acetaminophen. Acetaminophen is an active ingredient in many different prescription and nonprescription products, and it can be easy to overdose on acetaminophen if your healthcare provider is not very careful to calculate your total dosage of acetaminophen from all products (including intravenous acetaminophen). Make sure your healthcare provider knows if you take any other acetaminophen products.
  • Rarely, some people may have allergic reactions to intravenous acetaminophen. Notify your healthcare provider if you have any signs of a serious allergic reaction, such as:
    • An unexplained rash
    • Itching
    • Hives
    • Redness of the face
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
  • Intravenous acetaminophen is officially listed as a pregnancy Category C medication. This means that it may not be safe for use during pregnancy (see Ofirmev and Pregnancy). However, acetaminophen (the active ingredient in this medicine) is generally considered quite safe for use during pregnancy.
  • Intravenous acetaminophen passes through breast milk. However, it is generally considered safe for breastfeeding women and their infants (see Ofirmev and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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