Drugs Home > Intravenous Acetaminophen

Available by prescription only, intravenous acetaminophen is approved for relieving pain and reducing fever. It is the first and only intravenous form of acetaminophen and is administered every four to six hours. This medication works in the central nervous system (the brain and spinal cord) by blocking certain chemicals that cause inflammation and fever. Side effects may include headaches, nausea, and vomiting.

What Is Intravenous Acetaminophen?

Intravenous acetaminophen (Ofirmev™) is a prescription medication approved for the treatment of pain and fever. It is the first and only intravenous (IV) form of acetaminophen approved for use in the United States.
(Click What Is Intravenous Acetaminophen Used For? for more information, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, intravenous acetaminophen can cause side effects. However, not everyone who receives the drug will experience problems. In fact, most people tolerate it quite well.
If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
Common side effects of intravenous acetaminophen may include but are not limited to:
(Click Side Effects of Intravenous Acetaminophen to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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