Drugs Home > Ingenol Mebutate

Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to using this medication if you have:
  • A sunburn
  • Any other skin problems
  • Any allergies, including to medications, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Ingenol Mebutate to learn more, including information on who should not use the drug.)

How Does Ingenol Mebutate Work?

It is not entirely clear how ingenol mebutate works to treat actinic keratosis lesions, although it is known that it causes the cells of actinic keratoses to die.

Clinical Effects

This medication has been extensively evaluated in clinical studies. These studies compared ingenol mebutate to a placebo (a similar product that did not contain any active ingredients). These studies demonstrated that ingenol mebutate was significantly more effective than the placebo for eliminating actinic keratoses and genital warts. In studies, 28 percent to 47 percent of people using the drug had complete disappearance of their actinic keratoses, compared to only 2 percent to 5 percent of people using the placebo.
It is important to note that these results were measured on day 57 of the studies (almost two months after completing the treatment), so it should be expected that the results may take some time.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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