Drugs Home > What Is Fondaparinux Used For?

Fondaparinux is prescribed to treat and prevent blood clots in adults. It is specifically approved for use after certain surgeries, such as hip or knee replacement surgery. It works by slowing down clot formation, allowing the body to break down the clots naturally. Possible off-label uses for fondaparinux include preventing clots after moderate-risk general surgeries.

An Overview of Uses for Fondaparinux

Fondaparinux sodium (Arixtra®) is a prescription anticoagulant medication, commonly known as a "blood thinner."
Fondaparinux is approved to both treat and prevent blood clots deep inside the veins of the body, known medically as deep vein thrombosis (DVT). DVT clots typically occur in the legs or hips. It can be especially dangerous if the clot dislodges and travels to the lungs, where it may cause a pulmonary embolism (PE).
Specifically, fondaparinux is approved to prevent DVT blood clots in people who are undergoing the following types of surgeries:
Fondaparinux is also approved for use in combination with warfarin (Coumadin®, Jantoven®) to treat a DVT that has already happened. It can be used either in the hospital or outside of the hospital in people who have just had a DVT. However, if the more serious complication of a pulmonary embolism (PE) has occurred, fondaparinux should be used only in the hospital.
When used in combination with warfarin to treat a DVT or PE, the purpose of fondaparinux is to provide immediate and short-term anticoagulation while waiting for the warfarin to start working (it takes a few days for the warfarin to begin working adequately).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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