Drugs Home > Precautions and Warnings With Fluconazole

There are certain precautions and warnings with fluconazole that you should be aware of before starting the treatment. For example, it is important to know that this drug can cause liver damage, fatal skin rashes, and dangerous irregular heart rhythms. Although these problems are rare, they are still worthy of concern. In addition, you should not take fluconazole if you are taking cisapride.

What Should I Tell My Healthcare Provider Before Taking Fluconazole?

You should talk with your healthcare provider prior to taking fluconazole (Diflucan®) if you have:
  • Liver disease, such as liver failure, hepatitis, or cirrhosis
  • Heart disease
  • An irregular heart rhythm
  • Long QT syndrome
  • An electrolyte imbalance
  • Any other allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Fluconazole Warnings and Precautions

Some warnings and precautions to be aware of prior to taking fluconazole include the following:
  • Rare cases of liver damage (sometimes fatal) have been reported with fluconazole, usually in people with serious underlying medical conditions. Let your healthcare provider know right away if you develop signs of liver damage, such as:
    • Yellow eyes or skin (jaundice)
    • Upper-right abdominal pain (stomach pain)
    • Dark urine
    • Elevated liver enzymes (found using a standard blood test).
  • Fluconazole can cause severe, sometimes fatal, skin rashes. If you develop a rash while taking this drug, your healthcare provider should monitor you to make sure serious problems do not result.
  • In rare cases, this medication can cause severe, anaphylactic reactions.
  • Rare cases of certain irregular heart rhythms (known as QT prolongation and torsades de pointes) have been reported with fluconazole, usually in people who were already seriously ill and who also had other risk factors for such arrhythmias, such as heart disease or electrolyte imbalances.
  • Although a single oral dose of fluconazole is convenient and effective for treating vaginal yeast infections, it should be noted that studies suggest that this medicine is more likely to cause side effects compared to the standard vaginal treatments (such as yeast infection creams).
  • Fluconazole can interact with other medications (see Drug Interactions With Fluconazole).
  • Fluconazole is considered a pregnancy Category C or D medication, depending on the use. This means that it might not be safe for use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using this medicine during pregnancy (see Diflucan and Pregnancy for more information).
  • This medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, be sure to talk with your healthcare provider about using fluconazole (see Diflucan and Breastfeeding for more information).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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