Drugs Home > Etoposide VP-16

People with certain types of cancer may be prescribed a chemotherapy drug called etoposide. Also referred to as VP-16, etoposide was previously sold under the brand name Vepesid®; however, Vepesid is no longer being manufactured.
Etoposide is a podophyllotoxin derivative, meaning it is derived from the Mayapple tree (Podophyllum peltatum). It comes as a capsule that is taken by mouth and as an injection (Toposar®) that is given intravenously (by IV). Etoposide capsules are approved to treat small cell lung cancer. The injection is approved to treat small cell lung cancer and refractory testicular tumors (cancer of the testicles that has not adequately responded to other treatment).
The medication is also available in phosphate salt form as Etopophos® (etoposide phosphate), which is given by IV. Etopophos is approved to treat small cell lung cancer and refractory testicular cancer.
(For the full-length article, click Etoposide. This article takes a closer look at what this drug is used for, how it works, possible side effects, and dosing information.)
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Last reviewed by: Kristi Monson, PharmD;
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