Drugs Home > Doxylamine and Pyridoxine

Doxylamine and pyridoxine is a drug used to help reduce the symptoms of "morning sickness" in pregnant women who are unable to control nausea and vomiting through diet changes or other nonmedicine methods. This combination medication contains an antihistamine and vitamin B6. It comes as a tablet that is taken one to four times daily, depending on how you respond to the drug.

What Is Doxylamine and Pyridoxine?

Doxylamine and pyridoxine (Diclegis®) is a prescription medication approved to treat nausea and vomiting during pregnancy ("morning sickness") that has not adequately responded to dietary and lifestyle changes. It contains a combination of doxylamine, an antihistamine medication, and pyridoxine, which is vitamin B6
(Click What Is Doxylamine and Pyridoxine Used For? for more information, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, doxylamine and pyridoxine can cause side effects. However, not everyone who uses the drug will experience problems. Most people tolerate it quite well.
If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
Drowsiness is the most common doxylamine and pyridoxine side effect.
(Click Doxylamine and Pyridoxine Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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