Doxylamine and pyridoxine is a drug used to help reduce the symptoms of "morning sickness" in pregnant women who are unable to control nausea and vomiting through diet changes or other nonmedicine methods. This combination medication contains an antihistamine and vitamin B6. It comes as a tablet that is taken one to four times daily, depending on how you respond to the drug.
What Is Doxylamine and Pyridoxine?
Doxylamine and pyridoxine (Diclegis®) is a prescription medication approved to treat nausea and vomiting during pregnancy ("morning sickness") that has not adequately responded to dietary and lifestyle changes. It contains a combination of doxylamine, an antihistamine medication, and pyridoxine, which is vitamin B6.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Diclegis [package insert]. Bryn Mawr, PA: Duchesnay USA, Inc.;2013 April.
Food and Drug Administration (FDA) news release. FDA approves Diclegis for pregnant women experiencing nausea and vomiting (April 8, 2013). Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm347087.htm. Accessed May 25, 2013.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed May 25, 2013.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Hazardous Substances Data Bank (HSDB). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB. Accessed May 25, 2013.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind.
Site users seeking medical advice about their specific situation should consult with their own physician. Click