Drugs Home > Dinoprostone

Dinoprostone is a synthetic hormone-type substance that is important for the progression of labor and delivery. This product comes in several forms, including a vaginal insert, a vaginal gel, and vaginal suppositories. Depending on the product used, dinoprostone has various uses, such as causing contractions, terminating a pregnancy, or softening the cervix in preparation for delivery. Fever, vomiting, and diarrhea are possible side effects.

What Is Dinoprostone?

Dinoprostone (Cervidil®, Prepidil®, Prostin E2®) is a type of prostaglandin, a substance found naturally in the body that has hormone-like effects. Prostaglandins play an important role in the process leading up to labor and delivery. Dinoprostone is the active ingredient in several prescription medications, including:
Cervidil and Prepidil are used to relax and soften the cervix (this is known as cervical ripening) in preparation for induction of labor. Prostin E2 contains a higher dosage of dinoprostone. It is used to cause an abortion or to evacuate the womb (the uterus) after a missed abortion (missed miscarriage). It is also approved to treat a cancer-like condition of the uterus known as gestational trophoblastic disease.
(Click What Is Dinoprostone Used For? for more information on this topic, including possible off-label uses.)
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Last reviewed by: Kristi Monson, PharmD;
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