Drugs Home > Dinoprostone Vaginal Suppository

A healthcare provider may give a woman dinoprostone vaginal suppositories in several situations, such as to cause an abortion, to remove the contents of the uterus after a missed miscarriage, or to treat gestational trophoblastic disease. The suppository is inserted high in the vagina by a healthcare provider in a hospital setting. Vomiting, diarrhea, and fever are among the possible side effects.

What Is Dinoprostone Vaginal Suppository?

Dinoprostone vaginal suppository (Prostin E2®) is a prescription medication approved to cause an abortion or to remove any contents remaining in the womb (the uterus) after a "missed abortion" or "missed miscarriage" (when a fetus dies in the womb but is not naturally miscarried as normal). It is also approved to treat a cancer-like condition of the uterus known as gestational trophoblastic disease.
Dinoprostone vaginal suppositories contain dinoprostone, a hormone-type substance found naturally in the body. Cervidil® (dinoprostone vaginal insert) and Prepidil® (dinoprostone vaginal gel) contain lower doses of dinoprostone. They are used to prepare the cervix for induction of labor.
(Click What Is Dinoprostone Vaginal Suppository Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, dinoprostone vaginal suppositories may cause side effects. However, not everyone who uses the drug will experience problems. In fact, most women tolerate it quite well.
If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
Common side effects seen with dinoprostone vaginal suppositories include but are not limited to:
(Click Dinoprostone Vaginal Suppository Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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