Drugs Home > What Is Dextromethorphan and Quinidine Used For?

If you have uncontrolled laughing or crying episodes, you may benefit from dextromethorphan and quinidine. Specific uses for this prescription medication include treating adults who have pseudobulbar affect (PBA) that is associated with certain neurological conditions, such as Lou Gehrig's disease or multiple sclerosis. This drug is believed to work by affecting certain receptors in the brain.

An Overview of Uses for Dextromethorphan and Quinidine

Dextromethorphan and quinidine (Nuedexta™) is a prescription medication approved for the treatment of pseudobulbar affect (PBA).
PBA is a condition characterized by sudden episodes of involuntary, uncontrolled crying or laughing. These episodes occur even though there does not seem to be anything to laugh or cry about.
People with PBA have certain nervous system diseases or injuries that damage the area of the brain responsible for controlling the normal expression of emotions. Nervous system conditions that are associated with PBA include but are not limited to:
Dextromethorphan and quinidine has been shown to reduce crying and laughing outbursts in people with PBA. The effectiveness of this medicine for PBA treatment was studied in people with ALS and multiple sclerosis. It is unknown if the medication works to treat PBA associated with other conditions.
Although dextromethorphan and quinidine may work well for some people, not everyone will respond to the medication. Talk to your healthcare provider if your symptoms do not seem to improve or get worse while you are taking this medication.
Additionally, PBA will sometimes improve on its own, even without medication. Therefore, your healthcare provider may periodically take you off dextromethorphan and quinidine to see if you still need it.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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