Drugs Home > Dextromethorphan and Quinidine Side Effects

Some of the more common side effects of dextromethorphan and quinidine include diarrhea, dizziness, and vomiting. While these reactions generally require little or no treatment, potentially serious problems are also possible. If you experience more serious side effects with this medication, such as hallucinations, seizures, or abnormal bruising, notify your healthcare provider right away.

An Introduction to Dextromethorphan and Quinidine Side Effects

Just like any medicine, dextromethorphan and quinidine (Nuedexta™) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with dextromethorphan and quinidine. Your healthcare provider can discuss a more complete list with you.)

Serious Side Effects of Dextromethorphan and Quinidine

Some side effects of this drug are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Abnormal bruising or bleeding, such as:
    • Bruising easily
    • Bleeding of the gums or nosebleeds
    • Blood in the urine or stool
    • Unusual brown, red, or purple spots on the skin (which could be a sign of bleeding)
  • Loss of consciousness or fainting
  • An irregular, slow, or fast heartbeat
  • Hearing changes, loss of hearing, or ringing in the ears (tinnitus)
  • Vision changes or loss of vision
  • Seizures
  • Psychosis or unusual thoughts or behaviors
  • Changes in mood or mental status, such as:
  • Severe or persistent nausea, vomiting, or abdominal (stomach) pain
  • Fatigue or extreme tiredness or weakness
  • Pale skin color
  • Dark urine
  • Chills and fever
  • Shortness of breath
  • Muscle or joint pain
  • Loss of appetite
  • Yellowing of the skin or white of the eyes (jaundice)
  • Difficulty passing urine
  • Overactive reflexes
  • Muscle twitching or spasms
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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