Drugs Home > Side Effects of Dexlansoprazole

Chest pain, high blood pressure, and heart palpitations are some of the potentially serious side effects that may occur in people who are taking dexlansoprazole. These side effects should be reported to a healthcare provider immediately. However, in most cases, side effects of dexlansoprazole are minor and either do not require medical attention or can be treated easily. Some of these more common side effects include vomiting, diarrhea, and abdominal pain.

An Introduction to Dexlansoprazole Side Effects

As with any medicine, dexlansoprazole (Dexilant™) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with dexlansoprazole. Your healthcare provider can discuss a more complete list of dexlansoprazole side effects with you.)

Serious Side Effects Seen With Dexlansoprazole

Some dexlansoprazole side effects should be reported immediately to your healthcare provider. These potential side effects include, but are not limited to:
  • Signs of an allergic reaction to dexlansoprazole, such as:


    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing or difficulty breathing
    • Difficulty swallowing


  • An irregular heart rhythm (arrhythmia)
  • Chest pain (angina)
  • A slow heart rate (bradycardia)
  • Heart palpitations
  • A heart attack
  • Anxiety or depression
  • Blood clots in the legs
  • High blood pressure
  • Broken bones (some studies suggest this or other similar medications may increase the risk of bone fractures)
  • Signs of low blood magnesium (hypomagnesemia), such as:
    • Muscle spasm
    • An irregular heart rhythm (arrhythmia)
    • Seizures


It should be noted that these side effects occurred rarely in clinical studies, and there is a good chance that they are completely unrelated to dexlansoprazole.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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