Drugs Home > Claforan Drug Interactions

To help avoid potentially serious drug interactions with Claforan, your healthcare provider will ask you about all other vitamins, herbal supplements, and prescription and nonprescription medications you are taking. There are some antibiotics, birth control pills, and other products that may increase your risk for side effects, such as kidney damage, or cause the medications to become less effective.

An Overview of Interactions With Claforan

Claforan® (cefotaxime) may react with a few other products. Some of the drugs that can interact with Claforan include but are not limited to:
  • Aminoglycoside antibiotics, such as:
    • Amikacin (Amikin®)
    • Gentamicin
    • Kanamycin (Kantrex®)
    • Neomycin (Neo-Fradin®)
    • Streptomycin
    • Tobramycin

Claforan Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Claforan is combined with any of the drugs listed above.
Aminoglycoside Antibiotics
Combining Claforan with an aminoglycoside antibiotic may increase the risk of kidney damage. Nonetheless, in some very serious situations, such combinations may be used when the possible benefits outweigh the likely risks.
Birth Control Pills
Despite the long-standing belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics.
Ask your healthcare provider about whether you need to use a backup method of birth control while using Claforan (see Antibiotics and Birth Control Pills for more information). If it is very important to you to avoid pregnancy, you might consider using a backup method just to be safe.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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