Drugs Home > Carfilzomib Side Effects

Common Side Effects

Carfilzomib has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people receiving the drug were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In clinical studies, the most common carfilzomib side effects included:
  • Fatigue -- in up to 55.5 percent of people
  • Anemia (low red blood cell counts) -- up to 46.8 percent (see Chemotherapy and Anemia)
  • Nausea -- up to 44.9 percent
  • Low platelet counts (which could increase the risk for bleeding) -- up to 36.3 percent (see Blood Clotting Problems and Chemotherapy)
  • Shortness of breath -- up to 34.6 percent
  • Diarrhea -- up to 32.7 percent
  • Fever -- up to 30.4 percent
  • Upper respiratory tract infection (such as the common cold) -- up to 28.3 percent
  • Headache -- up to 27.6 percent
  • Cough -- up to 26 percent.
Other common reactions, occurring in 10.3 percent to 24.1 percent of people, included:
  • An increase in blood creatinine levels, which could be a sign of kidney problems
  • Swelling of the arms, hands, legs, ankles, or feet
  • Vomiting
  • Constipation
  • A low level of white blood cells, which could increase the risk for infection (see Chemotherapy and Infections)
  • Back pain
  • Insomnia
  • Chills
  • Joint pain
  • High blood pressure (hypertension)
  • Loss of strength and energy
  • Low levels of potassium in the blood (hypokalemia)
  • Low levels of magnesium in the blood (hypomagnesemia)
  • Arm and leg pain
  • Pneumonia
  • Increase in certain liver enzymes, which could be a sign of liver problems
  • Dizziness
  • Reduced sense of touch
  • Loss of appetite
  • General pain
  • High blood sugar levels (hyperglycemia)
  • Chest pain
  • High blood calcium levels (hypercalcemia)
  • Low blood phosphate levels (hypophosphatemia)
  • Low blood sodium levels (hyponatremia).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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