Drugs Home > Drug Interactions With Buprenorphine Patch

Potentially dangerous complications could occur if you take certain medications with the buprenorphine patch. Some of these drug interactions can increase your risk for side effects, such as difficulty breathing, memory loss, and low blood pressure. Alcohol, benzodiazepines, anxiety medications, and sleep medications are among the products that can lead to negative reactions with the buprenorphine patch.

An Overview of Buprenorphine Patch Interactions

The buprenorphine patch (Butrans®) is applied to the skin to treat moderate-to-severe chronic pain. It can potentially react with several other medications, since some of the active ingredient is absorbed into the bloodstream.
Some of the drugs that may interact with the buprenorphine patch include but are not limited to:
  • Alcohol
  • Benzodiazepines, such as:
  • CYP 3A4 inducer medications, such as:
  • CYP 3A4 inhibitor medications, such as:
  • Medications that cause drowsiness, such as:
  • Medications that cause a change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications)
  • Monoamine oxidase inhibitors (MAOIs), such as:
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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