Drugs Home > Bortezomib Side Effects

Some people who receive bortezomib will develop side effects during treatment. Some of the most commonly reported reactions include constipation, nausea, and a lack of energy. There are also some potentially dangerous problems that can occur, such as difficulty breathing, unusual bleeding, or seizures. Your healthcare provider can offer suggestions on how to prevent or minimize problems with this chemotherapy drug.

An Introduction to Side Effects of Bortezomib

Just like any chemotherapy medicine, bortezomib (Velcade®) can cause side effects, some of which can be quite significant. Talk to your healthcare provider about ways to prevent or lessen adverse reactions during treatment.
(This article covers many, but not all, of the possible side effects with bortezomib. Your healthcare provider can discuss a more complete list with you.)

Serious Bortezomib Side Effects

Some side effects of bortezomib are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Wheezing
    • Difficulty breathing or swallowing
  • Signs of an infection, such as:
  • Dizziness, lightheadedness, or fainting
  • Numbness, tingling, pain, or burning feelings in the hands or feet
  • Arm or leg weakness
  • A rash or skin reaction at the injection site
  • Shortness of breath, new or worsening cough, or difficulty breathing
  • Swelling of the legs, ankles, or feet
  • A persistent headache
  • Changes in vision, such as reduced or blurred vision
  • Increased blood pressure
  • Seizures
  • Signs of anemia, such as:
    • Unusual tiredness
    • Weakness
    • Pale skin
    • Shortness of breath
  • Black, tarry, or bloody stools
  • Unusual bleeding or bruising
  • Persistent nausea, vomiting, or diarrhea, especially if you cannot keep fluids down or stay hydrated
  • Yellowing of the skin or whites of the eyes (jaundice).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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