Drugs Home > Berinert

Berinert is a drug that is injected to relieve symptoms of sudden attacks of hereditary angioedema (HAE). This prescription medicine can help treat pain and swelling in the abdomen (stomach area), face, or throat that occurs during an HAE attack. The injections can be self-administered or given by your healthcare provider. Nausea, headaches, and abdominal pain are possible side effects.


What Is Berinert?

Berinert® (C1 esterase inhibitor) is a prescription medication approved to treat sudden attacks of pain and swelling in the abdomen (stomach area), face, or larynx (voice box) that can occur in people with hereditary angioedema (HAE). HAE is a rare genetic condition that causes episodes of swelling beneath the skin in various body parts.
Berinert belongs to a group of medicines known as C1 esterase inhibitors. Another C1 esterase inhibitor, Cinryze®, is approved to prevent HAE attacks from occurring. 
(Click Berinert Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Berinert is made by CSL Behring GmbH for CSL Behring, LLC.

Clinical Effects

In clinical studies, people with HAE who received Berinert had quicker relief of swelling and painful attacks than those who were given a placebo (an injection with no active ingredient). In one study, Berinert started to relieve the symptoms of a facial or abdominal HAE attack in a median of 48 minutes (the median is the middle number, meaning in half the people it took fewer than 48 minutes and in the other half it took longer than 48 minutes), compared with over 4 hours for those using a placebo.
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Last reviewed by: Kristi Monson, PharmD;
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