Drugs Home > Atovaquone/Proguanil

Atovaquone/proguanil is a drug that can be used for both the prevention and treatment of malaria. It comes in the form of a tablet and is typically taken once a day. This medication works by stopping the reproduction of Plasmodium parasites (the cause of malaria) in the bloodstream. Common side effects include nausea, headache, and diarrhea.

What Is Atovaquone/Proguanil?

Atovaquone/proguanil (Malarone®) is a prescription medication licensed to prevent or treat malaria. As the name implies, it is a combination of two antimalarial medicines: atovaquone and proguanil.
(Click What Is Atovaquone/Proguanil Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, atovaquone/proguanil can cause side effects. However, not everyone who takes the drug will experience problems. Most people tolerate it quite well.
If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious reactions are less common.
Some of the most common side effects seen with atovaquone/proguanil include but are not limited to:
  • Headache
  • Stomach pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Weakness, or a loss of energy and strength
  • Appetite loss
  • Dizziness.
(Click Side Effects of Atovaquone/Proguanil to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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