Drugs Home > What Is Artemether/Lumefantrine Used For?

Artemether/lumefantrine is approved to treat uncomplicated (mild) malaria in adults and children. It is not approved for use in children who weigh less than 11 pounds, and it may not be suitable for older adults who may have other medical problems. This drug is not used to prevent malaria; artemether/lumefantrine is only effective at treating the infection after it has begun.

An Overview of Uses for Artemether/Lumefantrine

Artemether/lumefantrine (Coartem®) is a prescription medication licensed to treat uncomplicated (mild) malaria. It contains two antimalarial medicines: artemether and lumefantrine.

Treating Malaria With Artemether/Lumefantrine

Malaria is a blood infection caused by a microscopic parasite called Plasmodium. It is a leading cause of death and disease worldwide, especially in developing countries. While there are over 100 species of Plasmodium, only four types of species infect humans. These four types include:
  • Plasmodium falciparum
  • Plasmodium vivax
  • Plasmodium ovale
  • Plasmodium malariae.
Most people get malaria from the bite of an infected female Anopheles mosquito. Less commonly, the disease is spread through contact with infected blood. Malaria is not transmitted from person to person, like the common cold or the flu. You cannot get the disease from casual contact with infected people (see Malaria Causes for more information).
Malaria symptoms typically begin 10 to 30 days after someone becomes infected. Malaria is categorized as uncomplicated or complicated, with symptoms ranging from mild in an uncomplicated infection to severe and life-threatening in complicated cases.
Early or uncomplicated symptoms of malaria include:
  • Fever
  • Sweats
  • Shaking chills
  • Headaches
  • Tiredness
  • Muscle aches
  • Nausea and vomiting
  • Diarrhea.
If the disease progresses, malaria may become complicated or severe. Severe malaria symptoms may include:
  • Kidney failure
  • Seizures
  • Mental confusion
  • Coma
  • Severe anemia
  • Fluid in the lungs (pulmonary edema)
  • Acute respiratory distress syndrome (ARDS)
  • Bleeding due to blood clotting problems
  • Death.
Severe malaria is almost always caused by P. falciparum. Most cases of severe malaria occur because people with mild or uncomplicated malaria do not get treated quickly enough. Severe malaria requires treatment in the hospital with intravenous (IV) medications.
The key to malaria treatment is starting early. With early treatment, malaria can be cured and the serious effects can be prevented. If treatment is delayed, malaria can be a severe and potentially fatal disease (see Malaria Treatment for more information).
Artemether/lumefantrine is one of several medications used to treat malaria. It is approved to treat uncomplicated, or mild, malaria caused by Plasmodium falciparum. It cannot be used to prevent a malaria infection.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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