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Lomustine Dosage

Some of the primary considerations that will affect your individual lomustine dosage include your height and weight. Other factors include how you respond to this drug and whether you are taking any other medications. Lomustine comes as capsules that are usually taken as a single dose once every six weeks. Your healthcare provider will closely monitor your blood cell counts during treatment.

An Introduction to Your Dosage of Lomustine

The dose of lomustine (CeeNU®) your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • Your height and weight
  • How you respond to and tolerate it
  • Other medications you are taking.
 
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 

Recommended Lomustine Dosing Guidelines

Like many chemotherapy medicines, lomustine dosing is based on body surface area, which is normally calculated using your height and weight. Doses based on body surface area are written as milligrams per meter squared (mg per m2).
 
The initial recommended dosage of lomustine to treat people with brain tumors or Hodgkin's lymphoma that have not been previously treated is 130 mg per m2 given as a single dose every six weeks. Because lomustine comes in capsules, the actual dose given is normally rounded to the nearest 10 mg. The usual recommended dose for people with reduced bone marrow function, such as those who have received other chemotherapy medicines, is 100 mg per m2 given as a one-time dose every six weeks.
 
People who are taking lomustine in addition to other chemotherapy medicines are normally given lower doses. Amounts are also normally reduced in people with impaired kidney function.
 
Lomustine can cause a significant decrease in blood cells. Your healthcare provider will monitor your blood cell counts weekly after each dose and adjust your next dose based on how low your blood cell counts drop.
 
Lomustine is given no more often than every six weeks, as it usually takes blood cell counts about six weeks to return to normal. However, your healthcare provider may recommend a longer break between doses if your blood cell counts remain too low.
 
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Lomustine Drug Information

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